Now offering custom senolytic compound development and clinical study services - The Xenohormesis Principle
In the harsh environments of high altitudes, extreme temperatures, and intense UV radiation, plants have evolved sophisticated molecular defense systems. Xenohormesis – the biological phenomenon where organisms benefit from consuming stress-response compounds produced by other species – offers a revolutionary approach to human longevity enhancement.
AI-Powered Botanical Discovery
Xenohormetine™ leverages advanced botanical bioinformatics and artificial intelligence to screen compounds from plants thriving in extreme environments. Our AI agent analyzes molecular structures, environmental stressors, and known longevity pathways to identify the most promising xenohormetic compounds.
Target Pathways for Longevity
Our research focuses on compounds that activate key longevity pathways:
AMPK Activation
The cellular energy sensor AMPK plays a crucial role in metabolic health and longevity. Stress-adapted plants produce compounds that naturally activate this pathway.
Nrf2 Pathway Enhancement
The master regulator of antioxidant response, Nrf2, is activated by plant compounds that have evolved to combat oxidative stress in harsh environments.
Sirtuin Upregulation
These “longevity proteins” are activated by plant polyphenols and other stress-response molecules, promoting cellular repair and survival.
Lead Compounds from Extreme Environments
Ergothioneine: The Longevity Amino Acid
Found in mushrooms and certain bacteria, this unique amino acid acts as a cellular protectant and has been linked to increased lifespan in multiple species.
Sulforaphane: The Cruciferous Champion
Derived from broccoli and other cruciferous vegetables, sulforaphane activates multiple longevity pathways and has shown remarkable anti-aging effects in preclinical studies.
High-Throughput Screening Innovation
Our reporter gene cell lines express fluorescent proteins when key longevity pathways are activated. This allows rapid screening of thousands of plant extracts to identify the most potent xenohormetic compounds.
Personalized Xenohormesis
The future of Xenohormetine™ lies in personalized medicine. We’re developing protocols to optimize compound combinations and dosages based on individual physiological status, genetic background, and health goals.
Environmental Sustainability
By focusing on compounds from hardy, stress-resistant plants, Xenohormetine™ promotes sustainable sourcing practices that don’t deplete sensitive ecosystems while providing powerful health benefits.