Now offering custom senolytic compound development and clinical study services - The Regenerative Medicine Revolution
Aging is fundamentally a loss of cellular regenerative capacity. As we age, our cells accumulate damage, lose their ability to repair themselves, and gradually decline in function. Juvenatine™ represents a paradigm shift in regenerative medicine, using natural compounds to restore cellular youth through epigenetic reprogramming and enhanced autophagy.
Epigenetic Reprogramming: Turning Back the Clock
Recent breakthroughs in cellular reprogramming have shown that aging is not irreversible. By modulating epigenetic marks – the chemical modifications that control gene expression – we can restore youthful cellular function without altering DNA sequence.
Alpha-Ketoglutarate (AKG): The Metabolic Rejuvenator
This key metabolite in cellular energy production also serves as a cofactor for epigenetic enzymes. Our research demonstrates AKG’s ability to promote healthy aging and extend lifespan across multiple species.
RJMP1: The Reprogramming Factor
Our proprietary reprogramming factor RJMP1 has shown remarkable ability to reset cellular age markers and restore regenerative capacity in aged cells.
The Autophagy Advantage
Autophagy – the cellular “housekeeping” process that removes damaged components – declines with age. Juvenatine™ has developed the world’s most comprehensive natural compound library for autophagy enhancement.
Spermidine: The Polyamine Pioneer
Originally discovered in sperm, this natural polyamine induces autophagy and has been linked to increased lifespan in organisms from yeast to humans.
Trehalose: The Cellular Cleaner
This natural sugar activates autophagy through TFEB upregulation, helping cells clear accumulated damage and restore function.
Urolithin A: The Mitochondrial Rejuvenator
Produced by gut bacteria from pomegranate compounds, Urolithin A specifically targets mitochondrial autophagy (mitophagy), replacing damaged cellular powerhouses with healthy ones.
Specialized Autophagy Pathways
Ferritinophagy: Iron Homeostasis
Our research includes compounds that specifically target ferritinophagy – the selective degradation of iron storage proteins – helping maintain healthy iron levels and prevent oxidative damage.
Mitophagy: Mitochondrial Quality Control
Beyond general autophagy, we focus on compounds that enhance mitochondrial-specific autophagy, crucial for maintaining cellular energy production.
The 1000+ Compound Library
Juvenatine™ maintains the world’s largest collection of natural autophagy-inducing compounds, systematically screened across different physiological levels:
- Cellular autophagy markers
- Tissue-specific responses
- Whole-organism effects
- Biomarker validation
Medical Foods and Dietary Supplements
Our research translates into practical applications through:
- Evidence-based formulations
- Standardized extracts
- Bioavailability optimization
- Safety validation
Clinical Translation
Juvenatine™ bridges the gap between laboratory research and clinical application through:
- Biomarker development for autophagy assessment
- Clinical study design for regenerative endpoints
- Regulatory pathway guidance
- Safety and efficacy validation
The Future of Regenerative Medicine
As we advance our understanding of cellular reprogramming and autophagy, Juvenatine™ is positioned to lead the development of natural, safe, and effective regenerative therapies that could fundamentally change how we approach aging and age-related disease.