Now offering custom senolytic compound development and clinical study services - The NAD+ Longevity Connection
Nicotinamide adenine dinucleotide (NAD+) is perhaps the most critical molecule for cellular energy production and DNA repair. As we age, NAD+ levels decline dramatically, contributing to mitochondrial dysfunction, genomic instability, and accelerated aging. Sirtivatine™ represents a comprehensive approach to NAD+ optimization through natural compounds and innovative combinations.
Beyond Simple Precursors
While NAD+ precursors like NMN (Nicotinamide Mononucleotide) and NR (Nicotinamide Riboside) have gained attention, Sirtivatine™ takes a holistic approach by addressing multiple aspects of NAD+ metabolism:
NAD+ Synthesis Enhancement
Our research includes next-generation precursors like NMNH and NRH, which may offer superior bioavailability and cellular uptake compared to traditional options.
NADase Inhibition
Compounds like Apigenin and various Berberine derivatives inhibit CD38 and other NAD±consuming enzymes, helping preserve cellular NAD+ pools.
NAMPT Upregulation
The rate-limiting enzyme in NAD+ salvage pathway, NAMPT, can be upregulated by specific natural compounds, enhancing the body’s ability to recycle NAD+.
Sirtivatine™ Lead Compounds
Astragalin: The Cellular Protector
This flavonoid glycoside not only supports NAD+ levels but also activates sirtuins directly, providing dual benefits for cellular longevity.
Fisetin: The Multi-Target Molecule
Beyond its senolytic properties, fisetin enhances NAD+ biosynthesis and supports mitochondrial function, making it a cornerstone of our formulations.
Pterostilbene: The Enhanced Resveratrol
With superior bioavailability compared to resveratrol, pterostilbene activates sirtuins more effectively while supporting NAD+ metabolism.
Trigonelline: The Coffee Compound
Found in coffee beans, this natural alkaloid has shown remarkable ability to boost NAD+ levels and improve metabolic health in preclinical studies.
Custom Research Capabilities
Sirtivatine™ offers specialized research services focusing on:
PARP Inhibition Studies
Poly(ADP-ribose) polymerases consume significant amounts of NAD+. Our research identifies natural PARP modulators that balance DNA repair with NAD+ conservation.
SLC25A51 Transport Optimization
This mitochondrial NAD+ transporter is crucial for cellular energy production. We’re developing natural compounds that enhance its function.
Clinical Applications and Biomarkers
Our comprehensive NAD+ assessment includes:
- Cellular NAD+/NADH ratios
- Sirtuin activity measurements
- Mitochondrial function markers
- DNA damage and repair indicators
The Future of NAD+ Therapy
As NAD+ research advances, Sirtivatine™ is positioned to lead the development of sophisticated, multi-target approaches that address the complexity of cellular energy metabolism and aging.